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Temperature-sensitive drug substances

In the pharmaceutical industry, it is essential to produce pure drug substance, suitable for human consumption, in a cost-effective manner. The purity of a drug substance can be checked by separation techniques such as GC, TLC, and HPLC. Both techniques tend to be more sensitive and specific than spectroscopic methods. HPLC has an advantage over GC as an analytical technique, since analytes need be neither volatile nor extremely stable to elevated temperatures. Highly accurate, almost universal detectors, such as... [Pg.188]

The storage conditions and the length of the studies should be sufficient to cover storage, shipment, and subsequent use. Both drug substances and products should be evaluated under storage conditions that test for thermal stability (temperature effect) and moisture sensitivity (humidity tolerance). [Pg.340]

Drug substance and carrier can be both in the glassy state. Total miscibility, partial miscibility, or total immiscibility has been observed. This type of system is very sensitive to temperature and moisture... [Pg.3745]

See other pages where Temperature-sensitive drug substances is mentioned: [Pg.220]    [Pg.207]    [Pg.26]    [Pg.220]    [Pg.207]    [Pg.26]    [Pg.27]    [Pg.349]    [Pg.454]    [Pg.87]    [Pg.574]    [Pg.127]    [Pg.95]    [Pg.243]    [Pg.654]    [Pg.440]    [Pg.318]    [Pg.544]    [Pg.358]    [Pg.54]    [Pg.60]    [Pg.547]    [Pg.395]    [Pg.11]    [Pg.244]    [Pg.121]    [Pg.3636]    [Pg.198]    [Pg.830]    [Pg.127]    [Pg.241]    [Pg.241]    [Pg.118]    [Pg.118]    [Pg.153]    [Pg.944]    [Pg.255]    [Pg.771]    [Pg.427]    [Pg.61]    [Pg.547]    [Pg.81]    [Pg.396]    [Pg.137]    [Pg.218]    [Pg.30]    [Pg.376]    [Pg.137]    [Pg.30]   
See also in sourсe #XX -- [ Pg.26 ]



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Drug substances

Temperature sensitivity

Temperature-sensitive

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