Temperature sensing phase-modulation

The fluorescence of quinine and the possibility of its quenching or modulation in the presence of external molecules could provide a method for sensing and assaying these molecules. For example, diastereomeric complexes of quinine and quinidine with (+ )-10-camphorsulfonic acid can be discriminated on the basis of their phase modulation-resolved fluorescence (different fluorescence lifetimes for QN and QD). Thus fluorescence lifetimes of 21.79 and 22.89 ns for QN and QD complex, respectively, have been measured, allowing a quantitative determination of QN and QD with a detection limit of 1.8 and 0.97 pM, respectively [142]. Similarly, room-temperature phosphorescence lifetimes were also shown to differ for diaste-reoisomeric complexes of QN and QD [143]. 

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