Temperature dependence of hydrophobicity enthalpy versus entropy stabilizations

3 Temperature dependence of hydrophobicity enthalpy versus entropy stabilizations 

The temperature dependence of hydrophobicity is interesting and has helped in understanding the phenomenon. With an increase in temperature of the solution from 0 °C, the solubility of a hydrophobic solute first decreases, reaches a minimum around 25 °C, and then continues to increase up to 100. Thus, the hydrophobicity 

The non-monotonic temperature dependence of hydrophobicity is a reflection of the fact that while hydrophobicity is entropic at room temperature, it is enthalpie at high temperature when the HB network breaks down and the entropie eost sharply decreases. 

Another interesting thermodynamic effect associated with hydrophobicity is the anomalous temperature dependence of the partial molar heat capacity of a hydro-phobic solute [7]. The partial molar heat capacity is large and positive in contrast to that of a non-hydrophobic solute. 

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