TCR, T-cell receptor

Figure 32.4. Cyclosporin A (CsA) disruption of signal transduction pathways leading to IL-2 production. CsA binds to cyclophilin in the cytoplasm. The complex disrupts at least two signaling pathways, decreasing activation of transcription factors AP-1 and NF-AT that lead to activation of genes involved in cytokine production. See text for detailed explanation. Abbreviations TCR, T-cell receptor PLC, phospholipase C IP3, inositol triphosphate PKC, protein kinase C DAG, diacylglycerol NF-AT, nuclear factor of activation PI, phophati-dylinositol PC, phosphatidylcholine.

NOEL no observed effect level TCR T cell receptor... 

Mature in thymus. immune response via TcRs (T-cell receptors) ... 

Fig. 13.8. A cytotoxic T cell and a helper T cell combining with a target cell and an antibody presenting celL respectively. The processed antigens are presented combined with MHC classes 1 and 11. TCR, T cell receptor.

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