Target promiscuity assessment

Compute the target hit rate (THR) in order to assess each compound for its selectivity or promiscuity across the whole panel of target assays. THR is defined as the ratio of the number of targets hit by a compound (>50% inhibition at a given concentration) to the number of targets tested at that concentration. 

Selectivity and Secondary Pharmacology Assessments The purpose ofminimizing promiscuity and enhancing selectivity is to reduce the potential for off-target effects, which are also known as secondary pharmacology effects. Both promiscuity and selectivity should be considered, as there is an important distinction between these traits. Promiscuity is a measure of the propensity of a molecule to bind other targets. 

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