Tandem Aza-Wittig/heterocumulene-mediated

Hoesl CE, Nefzi A, Houghten RA, Parallel solid-phase synthesis of 2-Imino-4-oxo-l,3,5-triazino[l,2-a]benzimidazoles via tandem Aza-Wittig/heterocumulene-mediated annulation reaction, J. Comb. Chem., 5 155-160, 2003. 

A tandem aza-Wittig/heterocumulene-mediated annulation route was developed for the efficient production of 6,7,8,9-tetrahydro-benzothieno[2,3-r/]-l,2,4-triazolo[l,5-a]pyrimidin-10(3F/)-ones <05S1601>, and an amine oxide rearrangement was key to the regioselective preparation of pyrrolo[2,3-J]pyrimidines <0581164>. Hexahydro-2-phenacylidene-pyrimidines gave -lactam fused 8-aroyl-2,3,4,5-tetrahydro-7-hydroxy-6//-pyrrolo[l,2-a]py-rimidine-6-ones when treated with (COCl), in the presence of NaH <05IJH87>, and methyl... 

Molina, P., Fresneda, P.M., and Almendros, P. (1992) A simple and general entry to aplysinopsin-type alkaloids by tandem aza-Wittig/ heterocumulene-mediated aimelation. Tetrahedron Lett., 33, 4491-4494. 

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