Tandem asymmetric dihydroxylation

Scheme 5.11. Tandem asymmetric dihydroxylation coupled with aldolase conditions. A = aldolase, P = PC>32. ...

Eyrisch, O, Sinerius, G, Fessner, W-D, Eacile enzymic de novo synthesis and NMR spectroscopic characterization of D-tagatose 1,6-bisphosphate, Carbohydr. Res., 238, 287-306, 1993. Henderson, I, Sharpless, KB, Wong, C-H, Synthesis of carbohydrates via tandem use of the osmium-catalyzed asymmetric dihydroxylation and enzyme-catalyzed aldol addition reactions, J. Am. Chem. Soc., 116, 558-561, 1994. 

Scheme 5.4 Example of a tandem Heck asymmetric dihydroxylation reaction.

Scheme 5.11. Tandem Heck-asymmetric dihydroxylation catalyzed by NAP-Mg-PdOs bifunctional catalyst.

Xu, Y., Jia, X., Panke, S., and Li, Z. (2009) Asymmetric dihydroxylation of aryl olefins by sequential enantiose-lective epoxidation and regioselective hydrolysis with tandem biocatalysts. Chem. Commun., 1481-1483. 

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