Tanaka-Scheraga method

The method by Tanaka and Scheraga will be exemplarily presented for the statistical-mechanical treatment of protein conformation because this approach has attained the highest popularity among all statistical-mechanical algorithms. 

Lenstra (1977) used data from 33 different proteins to compare four different methods of prediction, those of Argos and co-workers (1976), the stereochemical method of Lim (1974a,b) which is based on the relative positions of hydrophobic and hydrophilic residues, the statistical-mechanical method of Tanaka and Scheraga (1976a,b,c,d), and the statistical method of Nagano... 

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