Tanacetum microphyllum

By comparison, a series of mostly monoacylated flavonols is known to date and recent reports increased the number slightly. Four new products came from Pseudognaphalium robustum and Tanacetum microphyllum (both Asteraceae), and from Adina cordifolia (Rubia-ceae). A diacetylated compound (3,5-diacetyltambulin) was recently isolated from the bark of Zanthoxylum integrifoliolum (Rutaceae). Since most of the flavonols are monoacylated, the accumulation of quercetin tetraacetate in Adina cordifolia is a remarkable result. Altogether, the newly reported compounds occur scattered in the plant kingdom their occurrence is so far of little chemosystematic value. Aerial parts of Tanacetum microphyllum (Asteraceae) yielded a derivative, which is structurally not an ester. It is, indeed, a carbo-methoxy derivative of 6-hydroxyluteolin-4 -methyl ether (compound 34 in Table 12.5). No other flavonoid of this type is known so far. 

Martinez, J. et al.. Isolation of two flavonoids from Tanacetum microphyllum as PMA-induced ear edema inhibitors, J. Nat. Prod., 60, 142, 1997. 

Dihydroxy-4 -methoxy- 7-carbomethoxyflavonol Tanacetum microphyllum (Asteraceae) SLOX, COX... 

Hydroxyachillin (sesquiterpene lactone) Achillea millefolium, Tanacetum microphyllum (Asteraceae) [aerial] COX, SLOX [AI]... 

Constit. of Tanacetum microphyllum. Antiinflammatory agent. Cryst. 

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