Tamiflu, mechanism structure

Figure 4.18 The structure of Tamiflu (oseltamivir phosphate), an antiviral agent active against type A influenza, and a molecular model of its minimum-energy conformation, as calculated by molecular mechanics.

Due to the transfer mechanism of TcTS analogous to those of sialidases [25] the prototype of sialidase inhibitors Neu5Ac2en 99 [57] was tested. Compound 99 as well as the potent influenza virus neuraminidase inhibitors zanamivir (Relenza, 100) and the active form of oseltamivir (Tamiflu, 101) with analogous structures of transition state were also of interest as potential inhibitors of TcTS. However, as determined for 99 the TcTS activity was inhibited with only Ki = 12.29 mM (Fig. 15) [33]. 

---