Takasago Int. Corp

Catalytic asymmetric hydrogenation processes have been at the forefront of practical applications. Following the classical Monsanto s L-DOPA production using DiPAMP-Rh catalyst, BINAP-Ru catalysts have been used in the industrial synthesis of a P-lactam key intermediate to caibapenem antibiotics (Takasago Int. Corp.), 1,2-propanediol (50 tons/year),... 

R) -l,2-Propanediol formed by asymmetric hydrogenation of l-hydroxy-2-piopanone (50 tons/year at Takasago Int. Corp.) is used for the commercial synthesis of levofloxacin, an antibacterial agent (Dai-ichi Pharmaceutical Co.) [179g,228]. 

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