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Tadalafil Protease inhibitors

PROTEASE INHIBITORS PHOSPHODIESTERASE TYPE 5 INHIBITORS-SILDENAFIL, TADALAFIL, VARDENAFIL t sildenafil, tadalafil and vardenafil levels Inhibition of CYP3A4- and possibly CYP2C9-mediated metabolism of sildenafil Use with caution monitor BP closely. UK manufacturers recommend avoiding co-administration of vardenafil with protease inhibitors in patients >75 years. US manufacturers recommend using with caution, starting with a daily dose of 2.5 mg... [Pg.627]

Indinavir, saquinavir and ritonavir can cause marked rises in serum sildenafil levels. A fatal heart attack occurred in a man taking ritonavir and saquinavir when he also took sildenafil Similar marked interactions occur between vardenafil and indinavir or ritonavir, and are predicted to occur between vardenafil and the other protease inhibitors. Ritonavir caused less marked increases in tadalafil levels. [Pg.1273]

Protease inhibitors inhibit the aetivity of the cytochrome P450 isoenzyme CYP3A4, the enzyme that metabolises silden l, tadalafil and vardenafil. This results in an increase in their serum levels. Ritonavir is the most potent CYP3A4 inhibitor, followed by indinavir, nelfinavir, amprenavir, and then saquinavir, see Antivirals , (p.772)). [Pg.1274]

For tadalafil, the US manufacturer advises that the dose should not exceed 10 mg every 72 hours in patients taking ritonavir, whereas the UK manufacturer advises caution on concurrent use. It is probably prudent to apply this advice to patients taking any protease inhibitor. [Pg.1274]


See other pages where Tadalafil Protease inhibitors is mentioned: [Pg.1816]    [Pg.296]    [Pg.296]    [Pg.305]    [Pg.326]    [Pg.305]   
See also in sourсe #XX -- [ Pg.1273 ]




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