Tabletting machines Manesty

Tablet machine Manesty F speed 50 per min weight 490-510 mg. Strength test Diametral compression between flat-faced rams. Upper ram stationary, lower movi ng at 66 pm/s.

Figure 12.8. Operation and specifications of rotary tabletting machines (Carstensen, 1984). (a) Action of the punches of a rotary tabletting machine, (b) Specifications of a Sharpies Model 328 Stokes-Pennwalt Co.), (c) Specifications of a Manesty Rotapress Mk 11 Manesty Machines Ltd. and Thomas Engineering Inc.).

Figure 1 shows tablets (300 mg) of native dextran obtained from Leuconostoc mesenteroides B-512F (Sigma) with a 10% water (w/w) punch in an eccentric machine (Manesty) at 15 kN with tablet side (flat-flace diameter) 10mm. Axial displacement of water was observed according to the change in color. 

If large batches of oral dosage forms are necessary, usually the production of tablets is considered. Tableting machines for relative small batches are commercially available, e.g. Korsch XPl, Manesty B4, Optima 3000, Riva-Piccola. 

Tablet press subclasses primarily are distinguished from one another by how the powder blend is delivered to the die cavity. Tablet presses can deliver powders without mechanical assistance (gravity) (e.g., Ronchii, Manesty, Stokes, and Colton machines), with mechanical assistance (power assisted) (e.g., Ronchii, Courtoy, Kilian, Manesty, Kikusui, Fette, and Hata machines), by rotational forces (centrifugal) (e.g., the Comprima machine), and in two different locations where a tablet core is formed and subsequently an outer layer of coating material is applied (compression coating) (e.g., Kilian Manesty, and Kikusui machines).

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