Tablet tooling coatings

Work on expert systems in the specific domain of tablet film coating was initiated in April 1990, using a rule induction tool in order to develop a system for the identification and solution of defects in film-coated tablets. Although not strictly a formulation expert system, the developed system did contain knowledge whereby a given formulation known to cause defects could be modified to provide a solution. The completed system described by Rowe and Upjohn. 

Tsiftsoglou, T.B. Mendes, R.W. Effect of boron alloy coating of tableting tools. Pharm. Technol. 1982, 6 (April), 30-32, 36-38. 

T, Shen, Y, Taday, P.F., and Zeitier, J.A. (2009) Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating. Eur. J. Pharm. Biopharm.,... 

Examples of terahertz spectroscopy as a PAT tool in the pharmaceutical industry include monitoring of polymorphism, tablet coatings, and crystallinity, even at the stage of product development to aid in process design. ... 

Press-coated tablets were produced on modified rotary tablet machines using special tools with hollow punches, where first an inner tablet was formed and then the outer shell was compressed in the same die ( tablet-within-a-tablet ). ... 

Nickel-chromium-boron alloying coat applied on both punches and dies has been described and compared to untreated tools. Surprisingly, depending on the material under compression, the coating had the expected effect, or there was a total lack of effect, or they even increased ejection forces. The authors concluded that anyway, the tablets were superior in appearance. 

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