Tablet formulation implementation

Following the successful implementation of the tablet formulation expert system, a request was made for the development of a similar system for parenteral formulations. This project was initiated in April 1992, and completed in August 1992. The structure of the system is shown in Fig. 8. It is designed for formulating a... 

In 1994, due to the successful implementation of both this system and that used to formulate tablets, it was decided to initiate work on a new system that would recommend film-coating formulations for the generated tablet formulations, combined with a reformulation routine based on the film defect diagnosis system. The structure of the new system is shown in Fig. 11. The knowledge for the system was acquired by interviewing two domain experts, one with extensive heuristic knowledge and the other with extensive research knowledge. The sequence is as follows unital)... 

Tablets account for more than 80% of all pharmaceutical formulations therefore, the development and implementation of NIR methods for determining APIs in intact tablets is of a high interest with a view to assuring content uniformity and quality in the end product. Blanco et al developed an innovative strategy to prepare calibration samples for NIR analysis by using laboratory-made samples obtained by mixing the API and excipients in appropriate proportions and compacting the mixture at a pressure similar to that used industrially. This way of matching laboratory and production samples affords more simple and robust NIR methods which require the use of neither HPLC nor UV-vis spectroscopy as reference rather, reference values are obtained by weighing during preparation of the samples. The PLS calibration models thus constructed exhibited a good predictive ability with various production batches.

---