Tablet as a dosage form

Whereas solutions represent a state of maximum dispersion, compressed tablets have the closest proximity to particles. Since problems in 

Factors responsible for the primary breakdown of tablets into granules and their subsequent breakdown into finer particles include  

From the scheme in Fig. 9.4, it is clear that tablet disintegration and granule deaggregation are important steps in the dissolution and absorption processes. A tablet that fails to disintegrate or which disintegrates slowly may result in incomplete and/or slow absorption this, in turn, may delay the onset of action. 

The importance of disintegration in dmg absorption is evident from a study of dipyridamole (Persantine), a coronary vasodilator. In Fig. 9.5, 

Similar results have also been reported by Mellinger (1965) for thioridazine (Mellaril) tablets. 

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