T-amylalcohol

For the P-aminocarboxamides 134-137, CALA gave very low enantioselectivity. Because no ester function was present in the substrate, N-acylation proceeded satisfactory with CALB as the catalyst and trifluoroethyl butyrate as the acyl donor in t-butylmethyl ether/t-amylalcohol (TBME)/(TAME) mixtures at 45 °C (Scheme 4.40) [131]. 

Reagents and conditions i, AcaO, DMSO, [PhsPCHaJBr ii, NaH, t-amylalcohol... 

The spontaneous water-catalyzed hydrolysis of bis-(4-nitrophenyl) carbonate, (10), is only weakly inhibited by cationic micelles of CTABr, suggesting that their surface is highly aqueous [32], and cationic microemulsions of octane, CTABr and t-amylalcohol behave in exactly the same way [155]. 

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