Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Systems genetics validation

The only estimate of dominant effects in humans comes from mouse data. BEIR III and UNSCEAR both used skeletal anomalies and cataracts as a basis for human radiation-risk estimates. With chemicals, there are greater uncertainties in extrapolating from mouse to man. The skeletal and cataract systems have not been used widely enough for their validity to be assessed, but at present there is little choice but to use these if an estimate must be made. We suggest that the human impact in the first 5-10 generations be estimated as 4 times the first-generation estimate, as explained in Chapter 7. As is also discussed in Chapter 7, there is no feasible way to estimate the total genetic impact. [Pg.227]

See other pages where Systems genetics validation is mentioned: [Pg.338]    [Pg.125]    [Pg.220]    [Pg.410]    [Pg.17]    [Pg.176]    [Pg.915]    [Pg.1236]    [Pg.134]    [Pg.170]    [Pg.75]    [Pg.80]    [Pg.359]    [Pg.480]    [Pg.398]    [Pg.166]    [Pg.64]    [Pg.341]    [Pg.410]    [Pg.194]    [Pg.8]    [Pg.223]    [Pg.283]    [Pg.298]    [Pg.178]    [Pg.108]    [Pg.20]    [Pg.375]    [Pg.500]    [Pg.323]    [Pg.331]    [Pg.426]    [Pg.485]    [Pg.595]    [Pg.1]    [Pg.235]    [Pg.329]    [Pg.15]    [Pg.338]    [Pg.996]    [Pg.709]    [Pg.74]    [Pg.173]    [Pg.176]    [Pg.142]    [Pg.915]    [Pg.1236]    [Pg.252]    [Pg.172]    [Pg.609]   
See also in sourсe #XX -- [ Pg.191 ]



SEARCH



System validation

Systems genetics

© 2024 chempedia.info