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Synthon method

This discussion is separated into three sections depending on whether fluorine, or polyfluoroalkyl group, is introduced into a heterocycle or whether the heterocycle is formed from fluorinated synthons. Methods of introduction of fluorine into N-containing heterocyclic compounds have been reviewed (90CLY959). [Pg.2]

II. HIGHLY EFFICIENT SEMISYNTHESIS OF PACLITAXEL AND DOCETAXEL BY MEANS OF THE P-LACTAM SYNTHON METHOD... [Pg.72]

Our strategy was to apply the P-Lactam Synthon Method (P-LSM)47-49 developed in these laboratories for (i) the asymmetric synthesis of the (2 R,3 S)-N-ben-zoyl-3-phenylisoserine moiety with excellent enantiomeric purity in high yield, and (ii) the ring-opening coupling of A-acyl-P-lactams with DAB (3). [Pg.73]

The second chapter addresses new facets of the medicinal chemistry of the important anticancer drug Taxol (paclitaxel). Ojima and coworkers explore, in particular, the structure-activity relationship associated with the 3-phenylisoserine side chain, synthetically exploiting their P-Lactam Synthon Method . Their research has led to, among other things, a series of noteworthy second-generation taxoid anticancer agents. [Pg.337]

Ojima, I. Asymmetric Syntheses by Means of the Lactam Synthon Method, Adv. Asymm. Synth., Vol. I, Hassner, A., Ed., JALGreenwich, CT, 1995. [Pg.2]

Ojima, I. Asymmetric syntheses by means of the P-lactam synthon method. Adv. in Asymmetric Synth. 1995,1, 95-146. [Pg.683]

Ojima, I., Kuduk, S. D., Slater, J. C., et al. (1996) Syntheses of new fluorine-containing taxoids by means of (i-lactam synthon method. Tetrahedron, 52, 209-24. [Pg.136]

Ojima, I. (1995) Recent advances in P-lactam synthon method. Accounts of Chemical Research, 28, 383-389. [Pg.137]

Ojima, I., Habus, I., Zhao, M., et al. (1992) New and efficient approaches to the semisynthesis of taxol and its C-13 side-chain analogs by means of beta-lactam synthon method. Tetrahedron, 48, 6985-7012. [Pg.138]

Ojma I, Delaloge F (1997) Asymmetric synthesis of bmlding-blocks for peptides and pepti-domimetics by means of the -lactam synthon method. Chem Soc Rev 26 377-386... [Pg.467]

Ojima I (1993) /9-Lactam Synthon Method Enantiomerically Pure /9-Lactams as Synthetic Intermediates. In Georg GI (ed) The Organic Chemistry of /9-Lactams. VCH Publishers, Inc., New York, p 197... [Pg.206]

Ojima I (1995) Recent Advances in the /9-Lactam Synthon Method. Acc Chem Res 28 383... [Pg.206]

Ojima I, Sun CM, Zucco M, Park YH, Duclos O, Kuduk S (1993) A Highly Efficient Route to Taxotere by the / -Lactam Synthon Method. Tetrahedron Lett 34 4149... [Pg.207]

Ojima I, Kuduk SD, Slater JC, Gimi RH, Sun CM (1996) Syntheses of New Fluorine-Containing Taxoids by Means of /5-Lactam Synthon Method. Tetrahedron 52 209... [Pg.211]

Since the advent of penicillin, p-lactam antibiotics have occupied a central role against pathogenic bacteria. Moreover, more and more novel p-lactam antibiotics (Figure 4.3) have been developed due to bacterial tolerance and resistance. Special impetus for research efforts on p-lactam chemistry has been provided by the introduction of the p-lactam synthon method, a term coined by Ojima over 15 years ago, according to which 2-azetidinones can be employed as useful intermediates in organic synthesis. [Pg.384]

By the early 1990s, de novo syntheses of the paclitaxel side-chain and methods for coupling it (/3-lactam synthon method) with the baccatin III system had been published . [Pg.39]


See other pages where Synthon method is mentioned: [Pg.353]    [Pg.353]    [Pg.69]    [Pg.70]    [Pg.119]    [Pg.431]    [Pg.84]    [Pg.121]    [Pg.138]    [Pg.442]    [Pg.12]   
See also in sourсe #XX -- [ Pg.129 ]




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