Synthetic Receptors for Organic Guests

Receptors 25 and 26 were also amphfied from the same DCL when using ammonium cations as templates that are TSAs of a Diels-Alder reaction and of an acetal hydrolysis respectively [138, 139]. Kinetic experiments confirmed that both macrocycles are catalytically active (see Chapter 4 for a more detailed discussion). 

No amplification of the cyclic tetramer was observed on the contrary, the concentration of this species along with other macrocycles in the mixture decreased to feed amplification of the cyclic dimer 76 that increased in abundance from 9 to 45% of the library material. Direct experimental measurement of binding 

Discovery of this unpredictable and highly complex host through stereoselective amplificahon is a perhaps the most clear expression of the power of DCC as a tool for the development of new synthehc receptors. 

In all the previous examples, once amphfication of a receptor had been achieved, the reversible reachon was stopped and the template molecule removed to give a 

Related approaches have been used for the preparation of other mechanically interlocked molecules using different reversible processes, such as olefin metathesis [98, 148, 149] and disulfide exchange [150, 151], 

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