Synthetic Compounds for Treatment of Inflammation

Assignee The Regents of the University of California and Harbor Branch Oceanographic Institute 

Utility Treatment Anti-Immunogenic and Neurogenic Inflammation 

Two equivalents of indole were suspended in water, one equivalent of acetaldehyde dimethyl acetal added, and the mixture heated to 85 °C 5 hours in the absence of light. The precipitate that formed was re-crystallized in methyl alcohol and the product isolated in 59% yield, mp = 172°C. H-NMR data supplied. 

The preparation of other 3-substituted indole derivatives of the current invention are depicted, (I), (II), and, (III), and described, (1, 2, 3), respectively. 

Bis-heterocyclie analogues of the current invention such as Dragmacidin F, (IV), Topsentin D, and Topsentin E and their salts have been prepared and are reviewed (5). 

---