Synthetic biology aptamer

Bryksin, A.V., Brown, A.C., Baksh, M.M., Finn, M., Barker, T.H., 2014. Learning from nature-novel synthetic biology approaches for hiomaterial design. Acta Biomater. 10, 1761-1769. Bunka, D.H.J., Stockley, P.G., 2006. Aptamers come of age—at last. Nat. Rev. Microbiol. 4, 588-596. 

Fig. 3.4.1. Biological proteins or peptides are composed of naturally occurring L amino acids whereas all naturally occurring nucleic acids are composed of D sugars. If an isolated aptamer interacts with a protein target by building a stable complex, both structures composed of the synthetic mirror image form (enantio-target and enantio-aptamer) should...

B. Aptamers as Synthetic Antibodies" for Target Validation and Quantification in Biological Fluids... 

Another study also investigated the effect of various anti-Rev aptamers in vivo, but from a somewhat different angle. Symensma et al. substituted the wild-type Rev-binding element for the Rev-binding aptamer, and tested whether the synthetic Rev-binding RNA would still be able to substitute the biological function of the wild-type, i.e.Ao facilitate Rev-dependent mRNA transport [72]. Various classes of anti-HIV-1-Rev-binding aptamers were assayed One class closely resembled the wild-type sequence, whereas the... 

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