Synthetic Applications of Synphase Crowns

Schultz and co-workers have described a crown-based synthesis of 406 purines varying at the C-2 and C-6 positions.14 This library was targeted for 

Ellman s tetrahydropyranyl linker16 was used to attach the purine through the 9-position. 

A series of trisubstituted guanidines has been prepared by Drewry et al.19 a-Bromo-p-toluamide was converted to the azide by reaction with sodium 

SOLID-PHASE ORGANIC SYNTHESIS ON RADIATION-GRAFTED POLYMER SURFACES 

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