Synthesis via Solution-Phase One-Pot Assembly

98 in the same flask, this time in the presence of NIS and TfOH, gave the fully protected trisaccharide 100 in good yield. With a properly positioned Lev group, additional iterative deprotections and extensions of the oligomer using the thioglycoside [Pg.250]

99 provided a way to afford pentasaccharide 102 and heptasaccharide 104. A four-step transformation supplied the desired oligomers 105-107. [Pg.250]

SCHEME 10.10 Synthesis of HA oligomers involving one-pot assembly to the trisaccharide level. [Pg.251]

SCHEME 10.11 Anomeric reactivity-based one-pot assembly and preparation of a pentasaccharide based on heparin and HS. [Pg.251]

SCHEME 10.12 Preparation of hexasaccharides based on heparin and HS via preactivation. TTBP, 2,4,6-tri-tert-butylpyrimidinc. [Pg.252]

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