Synthesis Using Proazaphosphatrane

Preparation of homoallylic alcohols was achieved by reacting aromatic aldehydes with allyltrimethylsilane in the presence of 20mol% Pr-proazaphosphatarene base. Lower 

A new catalyst system for the synthesis of a-aryl substituted nitriles has been reported. The Bu-proazaphosphatrane serves as an efficient and versatile ligand for the palladium 

The proazaphosphatrane bases serve as an effective ligand for the palladium catalysed amination of a wide array of bromides and iodides. Other bicyclic or acyclic triaminopho-sphines, even those of similar basicity and/or bulk, were inferior. The palladium catalysed 

---

Proazaphosphatrane bases were used for palladium catalysed Stille reactions of aryl chlorides. These bases efficiently catalyse the coupling of electronically diverse aryl chlorides with an array of organotin reagents. The catalyst system based on benzyl (Bn)-proazaphosphatrane is active for the synthesis of sterically hindered biaryls. The use of the proazaphosphatrane allows room temperature coupling of aryl bromides and it also permits aryl triflates and vinyl chlorides to participate in Stille coupling [69] (Scheme 5.47). 

---