Synthesis of Trypanosoma cruzi GPI Anchor

The resultant diastereomeric mixture was deacetylated before being subjected to 4, 6 -0-benzylidine formation, at which point diastereomeric separation occurred to provide 110. Pseudodisaccharide 110, then, underwent 3 -0-benzylation followed by regioselective benzylidine ring opening using NaBH3CN to afford the 4 -alcohol 111. 

SCHEME 13.17 Completion of Vishwakarma s synthesis of the Trypanosoma cruzi GPI anchor. 

SCHEME 13.19 Completion of Nikolaev s synthesis of two Trypanosoma cruzi GPI anchors. 

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