Synthesis of the Trichoverroids

The isolation of trichodermadiene (72) marked the discovery of the newest class of trichothecene metabolites, the trichoverroids. As noted previously, these are derivatives of the simple sesquiterpenes which possess complex ester side chains, structurally related to those found in the macrocyclic trichothecenes, at C-4 or both C-4 and C-15 (see Table VIII). Evidence for their role as biosynthetic intermediates to the macrocyclic trichothecenes 42, 78) has spurred interest in their synthesis. 

The synthetic work on both the trichoverroids and the macrocyclic trichothecenes demands a good source of the sesquiterpene verrucarol (82). At first, this presented a problem as the main source of verrucarol (82) was the hydrolysis of verrucarin A (37), a macrocyclic trichothecene whose supply was somewhat limited. This problem has been rectified by Tulshian 

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