Synthesis of the Antithrombin-Binding Pentasaccharide Sequence in Heparin

3 Synthesis of the Antithrombin-Binding Pentasaccharide Sequence in Heparin (1984) [19, 20] 

This is the first synthesis of an oligosaccharidic fragment of heparin with a prominent biological activity [23]. 

It opened the door to a series of syntheses of other biologically active compounds containing variants of this pentasaccharide. 

This synthetic pentasaccharide and analogues are potential antithrombotic drugs devoid of certain detrimental side effects when compared with natural standard heparin [24], 

The hydroxyl groups which are going to be sulfated are protected by aeetyl groups, the hydroxyl groups being free in the final pentasaccharide are protected as benzyl ethers. 

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