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Synthesis of the Antithrombin-Binding Pentasaccharide Sequence in Heparin

3 Synthesis of the Antithrombin-Binding Pentasaccharide Sequence in Heparin (1984) [19, 20] [Pg.480]

This is the first synthesis of an oligosaccharidic fragment of heparin with a prominent biological activity [23]. [Pg.480]

It opened the door to a series of syntheses of other biologically active compounds containing variants of this pentasaccharide. [Pg.480]

This synthetic pentasaccharide and analogues are potential antithrombotic drugs devoid of certain detrimental side effects when compared with natural standard heparin [24], [Pg.481]

The hydroxyl groups which are going to be sulfated are protected by aeetyl groups, the hydroxyl groups being free in the final pentasaccharide are protected as benzyl ethers. [Pg.481]




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Antithrombin

Antithrombin heparin

Antithrombin heparin binding

Antithrombin in

Antithrombins

Heparin antithrombin-binding pentasaccharide

Heparin pentasaccharide sequence

Heparin sequence

Heparin synthesis

In the synthesis

Pentasaccharide

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