Synthesis of some sulfone-linked paracyclophanes from macrocyclic thioethers

Synthesis of some sulfone-linked paracyclophanes from macrocyclic thioethers 

Caution Carry out all procedures in a well-ventilated fume-hood, wear appropriate disposable gloves, a lab-coat, and safety glasses. 

450 mmol Glacial acetic acid, ca. 500 mL Anhydrous hydrogen chloride Hydrochloric acid (concentrated), 150 mL NaOH (5%), 200 mL 

Hydrogen peroxide (30% aqueous solution),10 mL Chloroform for extraction and chromatography 

To a single-necked round-bottomed flask equipped with a magnetic stirrer and a gas outlet tube which is connected to a water trap is added diphenyl sulfide (15.0 g, 80.0 mmol) and chlorosulfonic acid (30 ml). The mixture is stirred at room temperature for 8 h. 

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