Synthesis of p-Santalol

The synthesis starts from norbornanone (6.37). This is methylated using iodomethane with sodamide as the base. Alkylation of methyl-norbornanone (6.38), norbornanone (6.37) with Buchi s bromide (6.39) (prepared by addition of hydrogen bromide to acrolein in ethylene 

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As an example of the synthesis of p-santalol, we will look at that of Erman and Kretschmar, since it also illustrates two interesting points of general relevance. The overall scheme is shown in Figure 6.8. 

Scheme 15.12 Synthesis of the pheromone 2.6-dimethyl-1.5-heptadiene-3-n1 acetate. Scheme 15.13 Synthesis of p-santalol.

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