Synthesis of Optically Pure — -HA

Reagents a).Me2C03, NaH/KH, THE b) a-methylacrolein c) TMG, CH2CI2 or DBU, MeCN d) p-tolyl chlorothionoformate, Py e) pyrolysis f) ethyltriphenylphosphonimn bromide, n-BuLi, THF g) thiophenol, AIBN, toluene h) 20% NaOH, H20/THF/MeOH i) 2VHC1, dioxane j) (Ph0)2P(0)N3, Et3N, chlorobenzene k)MeOH  

1) pyrrolidine, molecular sieves, PhH m) propiolamide n) n-PrSLi, HMPA o) TMSl, CHCI3 p) MeOH. 

Illuminated by these promising results, several new chiral ferrocenylphosphine ligands were thus prepared. ° ° The enantioselectivity of the bicycloannulation 

Reagents and conditions a) RH, PhH, reflux, 3 days (91%) b).methacrolein, TMG, CH2CI2, rt (90%) c). MsCl, EtsN, DMAP, CH2CI2, rt NaOAc, HOAc, 110 °C. 

Reagents a) 11, (T -allyl)Pdcl, TMG, chiral ligand, toluene b) triflic acid, dioxane. 

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