Synthesis of N-acetyl-muramyl-L-alanyl-D-isoglutamine MDP

This section deals exclusively with the synthesis of MDP (1) itself (20, 30, 33, 35, 44, 50). Details of earlier preparations of N-acetyl-muramyl-peptides (5, 8, 39), although dealing with analogues of MDP, are mentioned occasionally. 

The general synthetic scheme can be summarized as follows suitably protected derivatives of both carbohydrate and peptide moieties are prepared first, then coupled and subsequently all the protecting groups are eliminated to give the free glycopeptide. Each step will be reviewed below. 

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Reichert, C. M., C. Carreu, M. Jolivet, F. Audibert, P. Lefranoer. and L. Chedid Synthesis of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP) containing conjugates and their use as a hapten-carrier system Mol. Immunol. 17, 357 (1980). 

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