Synthesis of Dichloro Methyl Phosphine MIO

0-Methyl methylphosphinate Mil could be prepared from the corresponding dichloro(methyl)phosphine MIO by reacting with methanol under anhydrous condition. MIO was very sensitive to water and easily oxidized, therefore, this reaction was protected from the atmosphere under anhydrous condition. 

There are several reports about the nucleophilic addition of 0-methyl methylphosphinate with aldehydes. The synthetic methods of 0-methyl (1-hydroxyalkyl)methylphosphinates M12 with different reaction conditions are summarized as three kinds of methods  

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Scheme 4.7 Synthesis of dichloro(methyl)phosphine MIO using chloromethane...

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