Synthesis of a Lead Compound

In creating synthetic routes for the development of drug molecules, the synthetic chemist wants to create a molecular entity in which functional groups (carbonyls, amines, etc.) are correctly positioned in three-dimensional space this will enable the creation of functional biophoric fragments such as the pharmacophore. The synthetic chemist has ten general classes of reactions available for such synthetic tasks  

These ten reactions provide the capacity to construct a molecular framework and then to position functional groups precisely on this framework. Accordingly, these ten reactions permit two fundamental construction activities  

Creation of C-C/C=C/C-H bonds (for the purpose of building a structural framework) 

Creation of functional groups (to give functionality to the framework) 

Appendix 3.1 at the end of this chapter lists 100 fundamental reactions used by synthetic medicinal chemists to create C-C bonds and functional groups during drug molecule preparation. Detailed discussion and mechanisms for these reactions are not provided, but are available in many textbooks of basic or advanced organic chemistry. 

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