Synthesis of a bis carceplex

Preliminary experiments in our laboratories suggest that carceplex 13 guest forms selectively in the presence of more than one suitable guest [23]. The range in selectivity observed was calculated to span two million-fold. 

2- pyrrolidinone, dimethyl sulfoscide (DMSO), ethyl methyl sulfoxide, thiolane-1-oxide, 

3- sulfolene, and 2-butanone [25]. The relative templating abilities of several guests were 

Reinhoudt s preparation of diastereomeric complexes 15 guest, each differing in the orientation of the contained guest, provided means for the discovery of a new form of stereoisomerism, carceroisomerism [26]. Application of these novel host-guest structures as molecular switches has been suggested [25, 26]. 

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