Synthesis continuous sequential combinatorial

An outstanding feature of the cation flow method is that the method enables continuous sequential combinatorial synthesis by simple flow switching as shown in Figure 6. In the first step, the cation flow generated from precursor A1 is allowed to react with nucleophile Bl. Then, the cation flow is allowed to react with the nucleophile B2. In the third step, the cation flow is allowed to react with nucleophile B3. Then, the precursor of the cation is switched to A2, and the cation flow generated from A2 is allowed to react with nucleophiles Bl, B2, and B3 sequentially. Then, the precursor of the cation is switched to A3, and the... 

The examples shown in this review article demonstrate that a variety of methods for polymer synthesis have been developed in flow microreactors. Continuous flow synthesis enables serial combinatorial synthesis, in which a variety of polymers can be synthesized in a sequential way using a single flow reactor with a flow switch. Space integration, which enables the synthesis of structurally well-defined polymers without isolating living polymer ends, also enhances the power and speed of polymer synthesis. Because several test plants for continuous production have already been built, there is no doubt that flow microreactors can contribute to polymer production in industry. 

The serial method based on continuous flow synthesis by simple flow switching is useful. Although the parallel method needs to use many reactors in parallel, the serial method needs to use only one flow reactor. Different substrates and/or reagents are fed sequentially to the inlets of the flow reactor and different products are produced sequentially at the outlet of the reactor. CtMitinuous operation of this system leads to synthesis of many different compounds in a combinatorial manner. 

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