Syntheses of Skyrin Model Systems

In the same year, Nicolaou et al. reported an interesting cascade reaction, in which it was possible to form model systems of skyrin (783), flavoskyrin (806, see Fig. 12.5), rubroskyrin (785), cytoskyrin A (789a), and the purported structure of rugulin (788). 

Nicolaou et al. obtained crystal structures of the model systems 811, 812, and 815. The crystal structures of the skyrin- and flavoskyrin-model systems are shown in Fig. 12.6. 

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