Syntheses of Peptides. The First Epoch

Five years before his summarizing lecture, Fischer had published (with E. Foumeau [2]) the preparation of the first dipeptide, glycylglycine, by partial HCl- 

After this introduction it would seem that no defined peptide bond had been produced prior to Fischers preparative work. However, he did not mention the experiments of Theodor Curtius (1857-1928) published from 1881 and 1882, who—unintentionally at first—had obtained and cleanly characterized benzoyl-glycylglycine (and higher homologs) by the interaction of benzoylchloride and the silver salt of hippuric acid (benzoylglycine). Fischer reported rather exactly on Curtius contributions to the development of peptide chemistry in his great 

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