SynPhase™ Crown coupling

This example describes the preparation of 10 SynPhase crowns coupled with threonine. 

The group of Schultz has synthesized a 406-member purine library on MD grafted SynPhase Crowns with varying substituents at the C2 and C6 positions.29 A common 2-chloropurine derivative was coupled onto... 

SynPhase Crowns with a Rink amide linker were used by Linn et al.38 at Glaxo-Wellcome to synthesize a library of 1,3,5-trisubstituted pyridin-2-ones (Scheme 12). The solid bound amide 38 was treated with 3-amino-5-methoxycarbonyl-l/f-pyridin-2-one with CS2CO3 in DMF to afford pyridine-2-one 39. Coupling of diphenylacetic acid FIATU and DIEA in... 

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