Synaptic targeting of AMPA receptors

Like NMDA receptors, AMPA receptors are also typically concentrated at postsynaptic sites of excitatory synapses. Recent evidence suggests, however, that the targeting of AMPA receptors to synapses is much more heterogeneous than that of NMDA receptors. Many excitatory synapses contain NMDA receptors but not AMPA receptors, especially early in development, and the content of AMPA receptors in AMPA receptor-positive synapses is quite variable (Nusser et al., 1998 Petralia et al., 1999 Takumi et al., 1999). Such morphologically silent 

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Chen CC, Lamping KG, Nuno DW, Barresi R, Prouty SJ, Lavoie JL, Cribbs LL, England SK, Sigmund CD, Weiss RM, Williamson RA, Hill JA, Campbell KP (2003) Abnormal coronary function in mice deficient in alphalH T-type Ca2+ channels. Science 302 1416-8 Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, Nicoll RA (2000) Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408 936 13... 

Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, et al. 2000. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408 936 43... 

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