Synapic potential mediation

The synapic potential mediated by non-NMDA receptors was recorded in normal ACSF. When ethanol (10-50 mM) was added to the perfusing medium, no significant change in non-NMDA receptor-mediated synaptic potential was observed. However, the addition of ethanol at a higher concentration (100 mM) induced a small reduction in non-NMDA receptor-mediated synaptic potential (Fig.(5)A). The reduction in non-NMDA response rapidly occurred after the addition of 100 mM ethanol and reached a steady state within 10 min. After washing out the ethanol, the response gradually returned to the normal level. When 10 pM crocin was added 10 min prior to the ethanol, the non-NMDA response was similarly reduced in the presence of 100 mM ethanol (Fig.(5)B). Crocin (10 pM) did not significantly affect the inhibitory effect of 100 mM ethanol on non-NMDA response (Fig.(5)C) [22],... 

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