Swinging cross-bridge model

Figure 14.12 The swinging cross-bridge model of muscle contraction driven by ATP hydrolysis, (a) A myosin cross-bridge (green) binds tightly in a 45 conformation to actin (red), (b) The myosin cross-bridge is released from the actin and undergoes a conformational change to a 90 conformation (c), which then rebinds to actin (d). The myosin cross-bridge then reverts back to its 45° conformation (a), causing the actin and myosin filaments to slide past each other. This whole cycle is then repeated.

Figure 14.17 A sequence of events combining the swinging cross-bridge model of actin and myosin filament sliding with structural data of myosin with and without bound nucleotides.

Spudich, J. A. 2001. The myosin swinging cross-bridge model. Nature Rev. Mol Cell Biol 2 387-392. 

Figure 2.15. A primitive swinging cross-bridge/ sliding filament model of muscle contraction is introduced for the purpose of providing a conceptual bridge from the simple oil-like dissociation/assoda-tion for the opening/closing of a clam-shaped globular protein toward the more complex structural aspects of muscle contraction. Major limitations in...

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