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Swainsonine structural studies

A detailed spectroscopic study has shown that swainsonine, from Swainsona canescens (Benth.) A. Lee, is 8a/3-indolizidine-la,2a,8 3-triol (1), and the structure and relative configuration have been confirmed by X-ray crystallography.1 Swainsonine is a potent inhibitor of a-mannosidase, and in animals it produces an accumulation of mannose-rich oligosaccharides in the lysosomal system of cells, leading to organ dysfunction and clinical disease.1... [Pg.59]

See other pages where Swainsonine structural studies is mentioned: [Pg.252]    [Pg.236]    [Pg.184]    [Pg.252]    [Pg.118]    [Pg.124]    [Pg.1523]    [Pg.1627]    [Pg.1635]    [Pg.1636]    [Pg.1636]    [Pg.2029]    [Pg.172]   
See also in sourсe #XX -- [ Pg.118 ]

See also in sourсe #XX -- [ Pg.118 ]



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Swainsonin

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