Swainsona canescens swainsonine from

Colgate, S. M., Dorling, P. R. and Huxtable, C. R. 1979. A spectroscopic investigation of swainsonine an a-mannosidase inhibitor isolated from Swainsona canescens. Austral. J. Chem. 32 2257-2264. 

A detailed spectroscopic study has shown that swainsonine, from Swainsona canescens (Benth.) A. Lee, is 8a/3-indolizidine-la,2a,8 3-triol (1), and the structure and relative configuration have been confirmed by X-ray crystallography.1 Swainsonine is a potent inhibitor of a-mannosidase, and in animals it produces an accumulation of mannose-rich oligosaccharides in the lysosomal system of cells, leading to organ dysfunction and clinical disease.1... 

Synthesis of ( )-Swmnsonine ( )-Swainsonine is an indoUzidine alkaloid that is isolated from the fungus Rhizoctonia leguminicola and later it was found in the AustraUan plant Swainsona canescens It is famous for its lysosomal mannosidase inhibiting activity. ( )-Swainso-nine is also well known for its antineoplastic activity as it is... 

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