Suzuki Miyaura sterically hindered substrates

In 2001, Fu s group [128] reported the application of Pd-triarylphosphane-ferrocene catalysts for the Suzuki-Miyaura reaction on aryl chloride substrates (Figure 1.40a). Activated aryl chlorides could be coupled at room temperature, while unactivated aryl chlorides, including sterically hindered and electron-rich substrates, at 70 °C. The triarylphosphane - which is air stable - was mixed with either Pd2(dba)j or Pd(OAc)2 with KjPO -HjO as base in toluene at room temperature, and very good yields were obtained. 

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