Suxamethonium Promazine

An isolated report describes prolonged apnoea in a patient given promazine while recovering from neuromuscular blockade with suxamethonium (succinylcholine). Recovery from the neuromuscular blocking effects of suxamethonium is prolonged by fenta-nyl/droperidoL... [Pg.117]

A woman recovering from surgery during which she had received suxamethonium, was given promazine 25 mg intravenously for sedation. Within 3 minutes she had become cyanotic and apnoeic, and required assisted respiration for 4 hours. ... [Pg.117]

Not imderstood. It has been suggested that promazine and droperidol depress plasma cholinesterase levels, which would reduce the metabolism of the suxamethonium and thereby prolong recovery. It has also been suggested that droperidol might act as a membrane stabiliser at neuromuscular jimctions. ... [Pg.117]

Some caution would seem appropriate if promazine is given to any patient who has been given suxamethonium. There seems to be no information about other phenothiazines and other neuromuscular blockers. [Pg.117]

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