Surface modification, CuAAC reaction

Another important applications of CuAAC reaction is its utility in surface modifications of a variety of substrates using small molecules and for the preparation of densely grafted polymeric brushes. The first demonstration of surface modification using click chemistry was by Collman et al., they utilized a m-azido alkanethiol, along with a simple alkanethiol, to first modify the surface of a gold-coated electrode by the formation of a self-assembled monolayer (SAM) and subsequently used CuAAC reaction with a suitable Ferrocene derivative... 

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