Supersensitivity, after denervation

A person who responds to an unusually low dose of a drug is called h y per reactive. Supersensitivity refers to increased responses to low doses only after denervation of an organ. At least three mechanisms are responsible for supersensitivity (1) increased receptors, (2) reduction in tonic neuronal activity, and (3) decreased neurotransmitter uptake mechanisms. 

Westfall DP, McPhillips JJ, Foley DJ. 1974. Inhibition of cholinesterase activity after postganglionic denervation of the rat vas deferens Evidence for prejunctional supersensitivity to acetylcholine. J Pharmacol Exp Ther 189 493-498. 

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