Sulphonamides for intestinal infections

A plethora of insoluble sulphonamide analogues, for instance phthalylsulfathiazole and succinylsulfathiazole, are not readily absorbed from the gastrointestinal tract. However, the release of active sulphonamide in high concentration, obtained due to hydrolysis in large intestine, enables their application for intestinal infections and also for pre-operative preparation of the bowel for surgery. A few examples of sulphonamides belonging to this specific use will be discussed here. 

Examples sulfaguanidine, phthalylsulfathiazole, succinylsulfathiazole, phthalylsulfacetamide, salazosulfapyridine, etc. 

N -(Diaminomethylene) sulfanilamide Benzenesulfonamide, 4-amino-N-(diaminomethylene)- N-/(-Aminobenzenesulfonyl guanidine monohydrate Sulphaguanid BPC 1973 NF XI Int. R Ind. P  

It may be prepared by eondensing /7-amino benzene sulfonyl ehloride with guanidine and hydrolysing the resultant in the presenee of sodium hydroxide. 

It has been used for the treatment of local intestinal infections, specifically bacillary dysentry, but it has mostly been replaced by comparatively less toxic analogues, namely phthalylsulphatiazole and succinylsulphathiazole. 

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See also in sourсe #XX -- [ ]

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