Sulphonacetamides, from sulphonamides

Reflux 1 g. of the sulphonamide with 2-5 ml. of acetyl chloride for 30 minutes if solution is not complete within 5 minutes, add up to 2-5 ml. of glacial acetic acid. Remove the excess of acetyl chloride by distillation on a water bath, and pour the cold reaction mixture into water. Collect the product, wash with water and dissolve it in warm sodium bicarbonate solution. Acidify the Altered solution with glacial acetic acid Alter oflF the precipitated sulphonacetamide and recrystaUise it from aqueous alcohol. 

Sulphonacetamides are derivatives of sulphonamides (Section 9.6.27, p. 1286), but since the latter are readily prepared from the sulphonic acids or their salts, sulphonacetamides may be employed for the characterisation of sulphonic adds for this reason they are included in this Section. 

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